A report today in a leading journal about a drug that doubles the physical endurance of mice running on treadmills. An ordinary lab mouse will run about one kilometer — five-eights of a mile — on a treadmill before collapsing from exhaustion. But mice given resveratrol, a minor component of red wine and other foods, run twice as far. Resveratrol has also been reported to extend the lifespan of mice.
They also have a reduced heart rate and energy-charged muscles, just as trained athletes do, according to an article published online in Cell by Johan Auwerx and his colleagues at the Institute of Genetics and Molecular and Cellular Biology in Illkirch, France.
He and his colleagues said the same mechanism seems likely to operate in humans, based on their analysis, in a group of Finnish subjects, of the gene that is influenced by the drug.
“Resveratrol makes you look like a trained athlete without the training,” Dr. Auwerx (pronounced OH-wer-ix”) said in an interview.
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